The Global Fund raises and invests money in three-year cycles known as Replenishments. We are heading towards the Global Fund 8th Replenishment which will be jointly hosted by the Republic of South Africa and the United Kingdom (UK).

The Global Funds Investment Case

The Global Fund launched its investment case in South Africa.  If you would like to listen to understand the position of the Communities, Developing and Developed Country NGO Delegations then click here to listen to Vitaly Djuma’s speech where he represented the three delegations.

To understand more about this, take a look at the Global Fund’s Investment Case and details how the requested financing will translate into desired goals: lives saved, infections averted, and even long-term economic gains achieved by reducing global disease burden.

The Investment Case shows how we will drive impact, save lives and deliver lifesaving tools and resources where they are needed most.

How to access the Investment Case

Eighth Replenishment Investment Case
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Executive Summary
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At a Glance
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The 8th Replenishment

This replenishment is not just about hitting a financial target—it is about reaffirming our commitment to the right to health, to human rights, to equity, and to the people at the heart of the response. This is a pivotal moment for global health. The progress we have made against HIV, TB, and malaria is at risk. The Global Fund replenishment is about more than money; it is about sustaining and accelerating the fight at a time when inequalities, human rights challenges, and emerging threats are converging.

It is a matter of life and death—but also a matter of smart investment. The evidence is clear:

• With $18 billion, the Global Fund could save 23 million more lives, on top of the 65 million already saved.
• It could prevent 400 million new infections.
• And every $1 invested generates $19 in economic returns.

The cost of inaction is even clearer: lost lives, increased drug resistance, and greater pressure on already fragile health systems.

This is a defining moment for our collective commitment to health equity, human rights, and the sustainability of the HIV, TB, and malaria response. Every funding decision, policy shift, and advocacy effort over the next year will determine whether we stay on track to end these epidemics—or allow them to resurge.