The Global Fund raises and invests money in three-year cycles known as Replenishments.

The Global Fund 8th Replenishment was jointly hosted by the Republic of South Africa and the United Kingdom (UK).

This replenishment is not just about hitting a financial target—it is about reaffirming our commitment to the right to health, to human rights, to equity, and to the people at the heart of the response. This is a pivotal moment for global health. The progress we have made against HIV, TB, and malaria is at risk. The Global Fund replenishment is about more than money; it is about sustaining and accelerating the fight at a time when inequalities, human rights challenges, and emerging threats are converging.

It is a matter of life and death—but also a matter of smart investment. The evidence is clear:

• the Global Fund could save 23 million more lives, on top of the 70 million already saved.
• It could prevent 400 million new infections.
• And every $1 invested generates $19 in economic returns.

The cost of inaction is even clearer: lost lives, increased drug resistance, and greater pressure on already fragile health systems.

This is a defining moment for our collective commitment to health equity, human rights, and the sustainability of the HIV, TB, and malaria response. Every funding decision, policy shift, and advocacy effort over the next year will determine whether we stay on track to end these epidemics—or allow them to resurge.

Thank you to those who have pledged!

Our Delegation thanks the private sector partners (CIFF and Takeda) and donors who have pledged early towards the eight replenishment such as Norway and those who have also increased their pledges such as Spain and Luxembourg. We appreciate your investment in global health.

On 21 November 2025, the Global Fund Partnership convened for the Global Fund’s 8th Replenishment Summit to save 23 million more lives and raised US$11.34 billion. The co-hosts’ call, (South Africa and the United Kingdom) for a transformative recommitment fell far short of what is needed, at a moment when failure is unaffordable and the stakes could not be higher.  

Today’s outcome reflects an uncomfortable truth: global health is not where it urgently needs to be on the political agenda. This shortfall will not only stall momentum, it will cost lives and we already see the Global Fund’s communication on the implications of this replenishment. Without increased support, we face the prospect of empty clinics, interrupted treatment, preventable deaths, and surges in new infections. A recent analysis suggests that cuts from European and US donors alone could result in 22.6 million deaths by 2030. This is not a projection – it is a warning of the scale of devastation that will follow if the world fails to act. 

See the Developing Country NGO Board member’s (Cecilia Senoo’s) speech speaking on behalf of the Communities and Developing and Developed Country NGO Delegations at the Replenishment Conference as well as the DCNGO Statement shared following the outcome.

The Global Funds Investment Case

The Global Fund launched its investment case in South Africa.  If you would like to listen to understand the position of the Communities, Developing and Developed Country NGO Delegations then click here to listen to Vitaly Djuma’s speech where he represented the three delegations.

To understand more about this, take a look at the Global Fund’s Investment Case and details how the requested financing will translate into desired goals: lives saved, infections averted, and even long-term economic gains achieved by reducing global disease burden.

The Investment Case shows how we will drive impact, save lives and deliver lifesaving tools and resources where they are needed most.

How to access the Investment Case

Eighth Replenishment Investment Case
download in English

Executive Summary
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At a Glance
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The Global Fund’s 8th Replenishment

This replenishment is not just about hitting a financial target—it is about reaffirming our commitment to the right to health, to human rights, to equity, and to the people at the heart of the response. This is a pivotal moment for global health. The progress we have made against HIV, TB, and malaria is at risk. The Global Fund replenishment is about more than money; it is about sustaining and accelerating the fight at a time when inequalities, human rights challenges, and emerging threats are converging.

It is a matter of life and death—but also a matter of smart investment. The evidence is clear:

• the Global Fund could save 23 million more lives, on top of the 70 million already saved.
• It could prevent 400 million new infections.
• And every $1 invested generates $19 in economic returns.

The cost of inaction is even clearer: lost lives, increased drug resistance, and greater pressure on already fragile health systems.

This is a defining moment for our collective commitment to health equity, human rights, and the sustainability of the HIV, TB, and malaria response. Every funding decision, policy shift, and advocacy effort over the next year will determine whether we stay on track to end these epidemics—or allow them to resurge.